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Vashisht P No data were found regarding the feasibility of the PGA. Thousand Oaks. Convergent validity is fulfilled indirectly in studies where the PGA is used as the gold standard to assess the construct validity of other indices. 2022 Sep;8(2):e002395. , Beaumont JL A 21-numbered circle visual analog scale (VAS) may be a desirable alternative to the traditional 10-cm horizontal line for pain and patient global estimate on a Multidimensional Health Assessment Questionnaire (MDHAQ). It should be noted that the PGA correlates with several other instruments that measure disease activity. The random effects model gives a more conservative estimate considering the heterogeneity. Thanou A, Chakravarty E, James JA, Merrill JT. A good responsiveness for PGA was shown in eight studies. , Petri M. Isenberg DA A total of 91 articles were included in the study (Fig. et al. An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA. 2014 Dec;53(12):2175-81. doi: 10.1093/rheumatology/keu153. , Petri M , Garabajiu M Annapureddy N , Henriques C official website and that any information you provide is encrypted , Buyon J , Farewell V The interRR was assessed in seven studies [4, 10, 11, 36, 65, 68, 94], showing values ranging from 0.67 [68] to 0.96 [94]. Content validity. For your privacy and protection, when applying to a job online, never give your social security number to a prospective employer, provide credit card or bank account information, or perform any sort of monetary transaction. Face validity. Physician training is very important. This important heterogeneity in the anchoring of the PGA prevented us from performing a meta-analysis of reliability data. , Carpenter AB , Friebus-Kardash J Discrimination refers to whether the score (PGA-VAS) differentiates between situations of interest [18]: discrimination of the PGA measures the ability of the PGA-VAS to report a consistent score where no change in disease activity has occurred (reliability) and to detect a change when a change in disease activity has occurred (sensitivity to change or responsiveness). et al. , McGwin G Published by Oxford University Press on behalf of the British Society for Rheumatology. , Holland M , Magder LS In 89 studies [2, 3, 913, 21102] the PGA was used to measure disease activity as a whole, therefore satisfying the content validity criteria. et al. , Hearth-Holmes M. Khan A Lead Medical Director heading up the global collaboration with Pfizer for Enbrel trials. In most studies, the PGA was assessed by a rheumatologist experienced in SLE care or research and, as already stated, the ICC reliability was different for an untrained physician and a trained investigator [36]. antineutrophil cytoplasmic antibody-associated vasculitis (AAV), and systemic lupus erythematosus (SLE). et al. , Bouter LM Deconstruction of the safety of estrogen in lupus erythematosus national assessment-systemic lupus erythematosus disease activity index flare index. Gladman DD The intrarater reliability (intraRR) is the ability to provide consistent scores in a stable population by the same assessor over time. , Fang H No study has evaluated the feasibility of the PGA in SLE to date. 8600 Rockville Pike An official website of the United States government. et al. Of note, it is not trivial that we found a good convergent validity with other instruments (SLEDAI, BILAG, LAI, SLAM and ECLAM) [10, 23, 24, 26, 28, 29, 35, 54, 68, 76, 84, 99]. The Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus (PISCOS) study aimed to obtain an evidence-based and expert-based consensus standardisation of the Physician Global Assessment (PGA) scoring of disease activity in systemic lupus erythematosus (SLE). The other authors have declared no conflicts of interest. CareerBuilder TIP. , Ding HH 2022 Jan 11;11(2):340. doi: 10.3390/jcm11020340. , Roberts WN , Jolly M. Mok CC Vil LM This concept includes content validity, face validity, construct validity and criterion validity. , Bertsias G Liang MH Published by Oxford University Press on behalf of the British Society for Rheumatology. The Patient's Global Assessment Scale (PGA) is the PRO counterpart to the Physician's Global Assessment Scale or Investigator's Global Assessment Scale (PGA-IGA). , Hynan LS RMD Open 2018;4:e000578. Disagreements between investigators were solved by consensus. Higher disease activity is an important predictor of both organ damage and mortality [2] and the attainment of low disease activity is associated with a reduction in early damage [5, 6]. [35], the PGA correlated, although moderately, with the need for treatment change (r=0.46, P<0.01). The Author(s) 2020. However, the PGA allows for the measurement of disease activity in a global way (content validity). , Esdaile JM. Definition: At least a 20%, 40%, 50%, or 70% improvement and an absolute improvement of at least 1 unit on a scale of 1-10 in at least three of the following criteria: patient global assessment; pain; function (BASFI); and. Keywords: Conducting medical monitoring, safety review, narrative writing and etc.. Perform medical assessment of individual . A PGA >1 was predictive of polymorphic light cutaneous eruption (P=0.02) [59] and correlated negatively with LLDAS attainment [37]. , ODell JR , Smiley A. Askanase AD Montreal, Canada Area. Touma Z , Dietzmann K , Arora S The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. Genetic linkage has related dysfunction of . , Chatzidionysiou K At least 1 issue from each virtual tour. PGA is often assessed by a single question with a 0-10 or 0 . , Ibanez D The https:// ensures that you are connecting to the , Chakravarty E disease activity). Arriens C Management of systemic lupus erythematosus (SLE) often depends on disease severity and disease manifestations, [] although hydroxychloroquine has a central role for long-term treatment in all SLE patients. Thus the development of a comprehensive index for assessing disease activity still represents one of the most important challenges in SLE [7]. Reliability measures the reproducibility of the instrument: it refers to the degree of agreement between different observers (interrater) and in the same observer over time (intrarater). HRQoL: Health-related Quality of Life; ICAM: intercellular adhesion molecule; VCAM: vascular cell adhesion molecule; MCP-1: monocyte chemoattractant protein-1; NC: non-calcified; suPAR: soluble urokinase plasminogen activator receptor; LFA-REAL: Lupus Foundation of America Rapid Evaluation of Activity in Lupus; CES-D: Centers for Epidemiological StudiesDepression scale; SLAQ: Systemic Lupus Erythematosus Activity Questionnaire; NA: not acquired; NS: not significant. Castrejn I, Ra-Figueroa I, Rosario MP, Carmona L. Reumatol Clin. The PGA is a well accepted and commonly used scale for evaluating treatment response in clinical trials both in adults and children. Construct validity. Direkt zum Inhalt springen . , Kandane-Rathnayake RK , Rairie JE SLE has protean and often complex manifestations, necessitating careful clinical assessment. Systemic lupus erythematosus (SLE) is a multisystem autoimmune rheumatic disease (ARD) characterized by flares and remissions. Content validity was reported in 89 studies. National Library of Medicine Accessibility et al. , Zonana-Nacach A Criterion validity was assessed exploring the PGA correlation with quality of life measurements, biomarker levels and treatment changes in 28 studies, while no study has evaluated correlation with damage. Thanou A , Wallace DJ , Petri MA Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus: the PISCOS study . 25 (FIVE YEARS 8) Latest Documents Most Cited Documents Contributed Authors Related Sources Related Keywords Latest Documents; Most Cited Documents; Contributed Authors; Related Sources; Nevertheless, despite the fact that the PGA was considered the reference in 39 studies involving other indices, it was used as the sole instrument in only 2 of them. In one study [25], the PGA of disease activity resulted from the combination of the clinical visit, laboratory markers evaluation and the physicians knowledge of the patient disease history. ~SLE~. Psychometric properties data were analysed according to the OMERACT Filter methodology version 2.1. PGA is a valid, responsive and feasible instrument, though its reliability was impacted by the scale adopted, suggesting the major need for standardization of its scoring. Several definitions of minimum clinically important difference were retrieved: in the SRI-4, a significant worsening was defined as an increase of >10% on the PGA-VAS [111], corresponding to 0.3 points from baseline; Touma et al. , Shea BJ et al. The correlation with the SLEDAI was determined in 12 studies (Fig. The PGA intraRR was assessed in three studies [10, 68, 94] and ranged from 0.55 [68] to 0.88 [10]. , Beresford MW , Annapureddy N , Cella D. van Vollenhoven RF A high variability in scales was found, causing a wide range of reliability (intraclass correlation coefficient 0.670.98). Epub 2014 Jul 10. , Wallace DJ et al. There is no cure for lupus, but medical . Funding: The study was funded through the training Bursary Programme 2019 of the SLEuro European Lupus Society. Merrill JT Quimby KR , OMalley T and transmitted securely. Liang MH may be asked to hyperventilate 3-4 min and watch a bright flashing light. In this systematic review we have analysed the measurement properties of the PGA, including the validity, reliability, responsiveness and feasibility. [9] for a disease activity index scored on a VAS ranging from 0 to 3, with an increase of 1.0 since the last visit indicating a flare. Changes in the PGA correlated with changes of other disease activity indices (SLEDAI, SLAM, LAI, patient global assessment), laboratory exams (ESR), patient-reported outcomes (Lupus Impact Tracker) [23, 50, 58, 77, 78, 81, 83] and response to treatment [4]. The index assesses separately eight organ-based systems. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of multifactorial origin that can affect any organ or organ system, resulting in a broad spectrum of clinical manifestations ranging from dermatological involvement to multi-organ failure with episodes of relapses and remissions. COSMIN Terminology from a European Rheumatology Perspective: a Glossary for the EULAR PRO Tool Box Initiative. , Vogel-Claussen J If you have a published paper from this period that does not appear on this list, please contact Sue Marone, who will add it to next week's collection. Physician's Global Assessment (PGA) score 1.0 on a 0 to 3 visual analog scale. et al. Objective: To examine the feasibility of using Physician Global Assessment (PGA) scores to collect and track patient acne and . , Urowitz MB. et al. , Sengupta M Provide oversight to Shared Services Derivatives team supporting RWA operations and production. Oxford University Press is a department of the University of Oxford. Results: According to the authors, this difference was probably due to the greater familiarity of the physicians with the BILAG-2004 index. The aim of this systematic literature review (SLR) is to describe and analyse the psychometric properties of PGA. Mertz P, Piga M, Chessa E, Amoura Z, Voll RE, Schwarting A, Maurier F, Blaison G, Bonnotte B, Poindron V, Fiehn C, Lorenz HM, Korganow AS, Sibilia J, Martin T, Arnaud L. RMD Open. The interrater reliability (interRR) of the PGA is the ability to provide consistent scores in a stable population between two or more physicians who evaluate the disease activity of the same patient. The Physician's Global Assessment (PGA) is a pragmatic disease activity measure, using a 100 mm visual analogue scale (VAS) for physicians to quantify the patient's overall disease . Objective Physician's global assessment (PGA) of disease activity is a major determinant of therapeutic decision making. Criterion validity. [2, 21, 24] recommended PGA assessment prior to reviewing serological data, based only on the clinical visit. , Askanase A , Bonithon-Kopp C AB - The Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus (PISCOS) study aimed to obtain an evidence . When expanded it provides a list of search options that will switch the search inputs to match the current selection. Truth refers to whether the measure provided by the scores is able to measure what was intended [18]. , Jnsen A , Magder L doi: 10.1136/rmdopen-2022-002395. , McGuire JL. , Magder LS However, it was used as a single outcome measure only in two studies [49, 100], while in the majority the PGA was scored together with another instrument (typically the SLEDAI) [2, 9, 11, 12, 21, 24, 30, 32, 34, 3740, 44, 45, 48, 49, 55, 58, 59, 61, 63, 64, 66, 67, 74, 75, 80, 82, 86, 8995, 103]. Additional papers were obtained by checking the references from the selected studies. Brunner HI Mokkink LB Exagen's products are used for therapeutic drug monitoring of hydroxychloroquine in whole blood and methotrexate polyglutamates, risk assessment testing, anti-TNF monitoring to individualize therapy and optimize dosing, and others. Three studies evaluated the association between PGA scores and treatment changes: PGA correlated negatively with adherence to treatment assessed through an item scale (r=0.31, P=0.11) [34]; clinically defined mild and moderate flares had a higher disease activity by the PGA (P<0.001) than those defined as mild/moderate flare only by medication changes [55]; PGA scores were associated positively with response to belimumab treatment (P=0.039) [43]. . (PGA), physician global assessment of disease activity (PHGA), C3, C4, and Anti-ds . All clinical diagnoses were verified by review of the patients' inpatient and outpatient files at the time of capillaroscopy. X 20 sentence examples within Physician Global Assessment. Gyri N PGA is a valid, responsive and feasible instrument, while its reliability was impacted by the scale adopted, suggesting the major need for a standardization of its scoring. , Maxwell LJ , Gomez A et al. global automatic chemiluminescence immunoassay analyzer market INTRODUCTION The chemiluminescence immunoassay system employs magnetic particle separation technology, which employs magnetic particles as antibody carriers and allows for even distribution of the carriers in the liquid phase reaction system, resulting in a faster and more effective . , Piette EW , Gladman DD. The LUMINA (Lupus in Minorities: Nature versus Nurture) study and other trials have offered evidence of a decrease in flares and prolonged life in patients given hydroxychloroquine, making . The literature search identified 91 studies. Comparison of the validity and sensitivity to change of 5 activity indices in systemic lupus erythematosus. , Gayet-Ageron A et al. In Fatemi et al. sharing sensitive information, make sure youre on a federal , Glassman DS To determine longitudinal associations between Physician Global Assessment (PGA) and patient-reported outcomes (PROs) in patients with systemic lupus erythematosus (SLE). It estimates how similar a given patients scores were at the two visits. , Skogh T Laboratory investigation results influence Physicians Global ssessment (PGA) of disease activity in SLE. , Kalunian K Because of its dynamic nature, this disease has an unpredictable natural course leading to high . , Sjwall C Your recommendations as to what might or should be done in relation to various issues observed. Meta-analysis of the studies reporting data concerning the construct validity between the PGA and SLEDAI. watch for seizures after the procedure. A PGA 2 correlated with a risk of pregnancy loss (29% vs 8%, P=0.005) [49]. , Saad-Magalhes C physician's global assessment (PGA) of disease activity in SLE. The Systemic Lupus Activity Measure-revised, the Mexican Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and a modified SLEDAI-2K are adequate instruments to measure disease activity in systemic lupus erythematosus. Cloud, mobility, security, and more. 12. and later incorporated into the SLE Responder Index used in the belimumab clinical trials, 13 The literature search identified 93 articles, and 12 additional articles were retrieved from the reference list of those publications. This may be explored through convergent and divergent validity. Jesus D , Bocci EB Would you like email updates of new search results? AU - Kandane-Rathnayake, Rangi. J Clin Med. Importance: In dermatology, the development of objective, standardized quality measures that can be used in a clinical setting is important to be able to respond to the needs of payers and credentialing and licensure bodies and to demonstrate dermatologic value. One study showed a significant ability of the PGA in distinguishing between patients (P<0.0001) and observers (P<0.0001), but not between visits [79]. Matthew Turk,1,2 Janet E Pope1,2 To cite: turk M, Pope Je. Over the years, PGA-IGA scales were modified for the purpose of clinical settings and thus present a diversity in the number of response options (4 to 10 points), the response options label and the . Help us improve CareerBuilder by providing feedback about this job: Report this job Job ID: 2281236908. The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity. et al. , Hochberg M. Touma Z For instance, in an analysis of studies of the prevalence of SLE in the Asia-Pacific region, higher rates of renal involvement were observed in Asian patients (21-65% at SLE diagnosis and 40 . Devilliers H It is therefore desirable to use the PGA along with other tools (typically the SLEDAI) or to include the PGA in a composite index (e.g. Retrieved papers were selected with no limitation on the year of publication, language or patients age. The PGA is usually reported by experts as allowing exhaustive coverage of the concept of disease activity in SLE [20, 108]. Navarra SV X 20 Physician Global Assessment 10.1136/lupus-2019-lsm.176 . , Dyer JW While specific studies remain to be performed to determine the optimal method for scoring the PGA, this literature search showed that the most adopted form of PGA was a 10cm 03 VAS with anchors (0, none; 1, mild; 2, moderate; 3, severe activity) [3]. , Chizzolini C , Allen E Uribe AG, Vil LM, McGwin G Jr, Sanchez ML, Reveille JD, Alarcn GS. , Klein-Gitelman MS Different scores and lengths of visual evaluation were employed: the first was the 010 VAS suggested by Liang et al. For permissions, please email: journals.permissions@oup.com, This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (. Fanouriakis A Barr SG , Patrick DL An international panel of 79 SLE experts participated in a three-round Delphi consensus . In support of its face validity, the PGA was used to define the disease activity score in all 91 studies retrieved by the literature search, having a role as an outcome measure as well as a comparator to assess the validity of other indices. The measurements were in the form of a scale from 0 to 3 in 54 studies [2, 3, 9, 10, 12, 13, 21, 2469, 103], a 010 scale in 12 studies [4, 60, 7079], a 0100 scale in 9 studies [27, 40, 78, 8085], a 07 Likert scale [11, 78, 80], a 02 scale [53], a 04 scale [86] and a 05 scale [87]. , Larson MG FitzGerald and Grossman [10] found a good interRR in a retrospective assessment of the PGA (=0.79). independently selected the articles, initially on the basis of titles and abstracts, then, if necessary, on the full texts, an eligibility assessment was performed independently in a blinded standardized manner. . , Hambleton IR Impact of anti-SARS-CoV-2 antibodies of different isotypes (IgA, IgG, IgM) on attainment of PGA . , Perneger T Bethesda, MD 20894, Web Policies et al. The search strategy for SSc-related publications identified 75 citations . , Karp DR http://oml.eular.org/glossary (31 January. It can affect the joints, skin, brain, lungs, kidneys, and blood vessels. The last EULAR/ACR recommendations recommended use of the PGA in the routine monitoring of SLE [16]. et al. Even though the PGA showed optimal reliability, a very low interRR for flare using the PGA (ICC=0.18) was found in a single study [65] compared with that of the BILAG (ICC=0.54) or SFI (ICC=0.21). , Andreoli L Chaigne B et al. The Janus kinase (Jak)/signal transducer and activating protein (STAT) pathways mediate the intracellular signaling of cytokines in a wide spectrum of cellular processes. Finally, the PGA enables the measurement of disease activity globally compared with a glossary-based index. 1), accounting for 49 longitudinal cohort studies, 25 cross-sectional studies, 7 randomized controlled trials, 3 consensus conferences, 4 post-hoc analyses, 2 retrospective studies and 1 case series. This study assesses the reliability of the PGA, measured by means of 0-100 mm visual analog scale (VAS), and the additional use of separate VAS scales for musculoskeletal (PhysMSK) and dermatologic (PhysSk) manifestations in patients with psoriatic arthritis (PsA). , Suriano A Karol DE European League Against Rheumatism. A validation study of the SRI for juvenile SLE [60] showed that exclusion of the BILAG or PGA from the SRI did not change the accuracy of the SRI in detecting improvement. This site needs JavaScript to work properly. , Block JA JSS Medical Research. Content validity pertains to the degree to which the instrument measures all facets of a construct of interest [20]: this property is satisfied if the PGA is considered able to measure all aspects of disease activity in SLE in a comprehensive way. et al. Face validity is satisfied when the instrument is considered able to capture what it should capture (i.e. . The company serves physicians and patients. , Goldsmith CH , Urowitz MB Results. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). , Petri M. Foering K , Pilkington C The results are similar, and less than half the time is required for scoring. [80] considered worsening as any increase in the PGA from baseline; in the epratuzumab trial [87], a significant improvement was a 20% decrease in the PGA score evaluated after 12months of treatment. , Alarcn GS RN-BSN HOLISTIC HEALTH ASSESSMENT ACROSS THE LIFESPAN (NURS 3315) Sociology of Social Problems (SOC213) , Tetzlaff J Newark, New Castle, USA, March 03, 2023 (GLOBE NEWSWIRE) -- The global complement-targeted therapeutics market is expected to grow at a CAGR of 8.9% from 2022 to 2030, owing to the rising . A difference between the interRR of the PGA assessed by an untrained physician (ICC=0.50.63) or a trained investigator (ICC=0.790.81) was found [36]. A high variability in scales was found, causing a wide range of reliability (intraclass correlation coefficient 0.67-0.98). , Petri M. Furie RA Different definitions of disease activity according to the PGA instrument. Objectives Remission in systemic lupus erythematosus (SLE) is defined through a combination of 'clinical SLE Disease Activity Index (cSLEDAI)=0', 'physician's global assessment (PGA) <0.5 . , Mina R Responsiveness, or sensitivity to change, is the usefulness of a test to detect minimum clinically important differences [20, 109]. A systematic review of the literature was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines [17], searching for articles reporting on the use of PGA in SLE. 2022 May;9(1):e000700. [8] and adopted in childhood SLE; the most common tool (the 03 VAS) was developed [68] to capture the concept of flare and is measured on a 3cm VAS in the SRI [3] and a 10cm VAS in the SFI [10, 104], but other scores (02, 04, 05, 07) [11, 53, 78, 80, 86, 87] and lengths (8cm, 15cm) [10, 8284] have also been used. In two studies, the PGA-VAS was used to assess concepts other than disease activity: disease severity [4] and patients compliance with treatments [103]. This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Psychometric properties data were analysed according to the OMERACT Filter methodology version 2.1. 2022 Mar 14;24(1):70. doi: 10.1186/s13075-022-02756-3. In 16 studies the PGA was used as a mean to assess changes in disease activity after treatment [3, 12, 22, 29, 40, 42, 43, 52, 54, 56, 57, 80, 85, 87, 95, 98, 101]. , Tanangunan R Five studies have demonstrated good ICC values for reliability (all >0.60 and ranging up to 0.97). , Pego-Reigosa J-M et al. [8] suggested the need for a disease activity instrument that would be valid, reliable and sensitive to change. 2021 Apr 8;5(1):33. doi: 10.1186/s41687-021-00298-x. In the absence of a consensus, Aranow [26] found a better correlation between the SLEDAI and the PGA when the latter was assessed taking into account laboratory test results. Methods: This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items . , Wetter J , Matos A PMC The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinicians judgement of overall SLE disease activity. ECG - correct answer no sleep the night before, meals allowed, no stimulants/tranquilizers for 24-48 hours before. SLE2ACR1997SLICC2012. Kandane-Rathnayake R, Louthrenoo W, Hoi A, Luo SF, Wu YJ, Chen YH, Cho J, Lateef A, Hamijoyo L, Navarra SV, Zamora L, Sockalingam S, An Y, Li Z, Katsumata Y, Harigai M, Hao Y, Zhang Z, Kikuchi J, Takeuchi T, Basnayake BMDB, Chan M, Ng KPL, Tugnet N, Kumar S, Oon S, Goldblatt F, O'Neill S, Gibson KA, Ohkubo N, Tanaka Y, Bae SC, Lau CS, Nikpour M, Golder V, Morand EF; Asia-Pacific Lupus Collaboration. , Petri M. Iaccarino L Your comment will be reviewed and published at the journal's discretion. PGA; disease activity; physician global assessment; psychometrics; systemic lupus erythematosus. , James JA et al. , Ibaez D Reliability was excellent when scored through a pointed scale, such as the Likert scale, that was anchored in unit numbers from 0 (not active) to 7 (most active) (interRR ICC 0.96; intraRR ICC 0.88) [80], but was lower when assessed through a centimetric VAS using values between 0.0 and 3.0 (interRR ICC 0.67; intraRR ICC 0.55) [68]. Patient-reported outcomes (PROs) reflect the patient's perspective and are used in rheumatoid arthritis (RA) routine clinical practice. PGA is an important tool for assessing disease activity, response to treatment (it is a component . SLE is an autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage in the affected organs. The Physician's Global Assessment (PhGA) is a number without unit. disease activity in SLE, with the Physician Global Assessment (PGA) being the only one included in the updated EULAR recommendations for the management of SLE.11. The authors wish to thank Sylvie Thuong for her invaluable assistance in the preparation of this manuscript. , Leung HW In a post-hoc analysis of phase 3 belimumab trials, improvements and no worsening in the PGA were greater among SRI responders vs SRI non-responders (P<0.001) [52]. doi: 10.1136/lupus-2022-000700. , Giangreco D The pooled correlation coefficient (95% CI) is given both for the fixed effects model and the random effects model. In an epratuzumab trial, the absence of deterioration of the PGA (not >10% worsening) was one of the items to achieve a BILAG-based Composite Lupus Assessment (BICLA) response [105]. , Adamichou C , Bentow C The patients were diagnosed as having the following disorders: scleroderma (n = 27), dermatomyositis (n = 11), systemic lupus erythematosus (SLE) (n = 22), MCTD (n = 8), and RP without evidence of underlying CTD (n = 38). In 32 studies, disease activity measured by PGA was compared with changes in laboratory markers, with the aim of correlating clinical and serological features [9, 21, 30, 32, 34, 3739, 44, 45, 48, 49, 55, 5861, 63, 64, 66, 67, 69, 71, 74, 75, 82, 86, 89, 9194]. MD globals may vary based on their age, gender, practice setting and experience (number of patients seen per year and years in practice). 215 (FIVE YEARS 146) H-INDEX. government site. This enabled the PGA to be considered the gold standard in several studies [2, 10, 11, 21, 23, 49, 67, 76, 78, 84, 88]. Pincus and colleagues conducted a study of . The literature search identified 91 studies. Clinical composite measures of disease activity and damage used to evaluate patients with systemic lupus erythematosus: A systematic literature review. Ann Rheum Dis 2 Isenberg DA, Allen E, Farewell V, et al. , Schur PH. , Mokkink LB et al. , Floris A , Voskuyl A Rendas-Baum R, Baranwal N, Joshi AV, Park J, Kosinski M. J Patient Rep Outcomes. Physician Global Assessment (PGA) is a visual analogue score (VAS) that reflects the clinician's judgment of overall Systemic Lupus Erythematosus (SLE) disease activity.