The list goes on a bit further, as the OPCs in thisextract may inhibit lipid peroxidation, platelet aggregation, capillary permeability and fragility, and to affect enzyme systems, which basically means it may be a natural treatment for many serious health conditions, such as stroke and heart disease. No side effects were noted, unlike its synthetic counterpart. This article is based on scientific evidence, written by experts and fact checked by our trained editorial staff. Potential benefits of folic acid include a reduced risk of cancer, improved cognitive function, stronger bones, enhanced heart health, better pregnancy outcomes and reduced symptoms of restless legs syndrome. Optimal doses of pycnogenol have not been set for any condition. We do not aim to diagnose, treat, cure or prevent any illness or disease. Regulations set manufacturing standards for supplements, but that does not guarantee that they are safe or effective. DOI: Gulati OP. This article explains which supplements are believed to be safe during pregnancy and which ones you should avoid. A trial of 84 people found that both Pycnogenol oral supplements and creams (0.5%) may prevent hemorrhoids from bleeding during acute attacks after 7 days. In a good-quality study, 100 patients with osteoarthritis of the knee were treated for three months either with 150 mg of Pycnogenol a day or placebo. Another 2006 study examined the effects of the antioxidant activity of pine bark extract on oxidative stress, which is thought to be one of the nongenetic factors contributing to ADHD. Pycnogenol seems well-tolerated for use in adults for up to 6 months. Pine bark extract can be found in liquid, tablet or capsule form containing 85 percent to 90 percent OPCs. A study was conducted by the Guang An Men Hospital of Chinese Medical Science Research Institutewith 77 diabetes type II patients to determine if theextract of the French Maritime pine bark provided anti-diabetic effects. In a clinical trial of 116 women, Pycnogenol (60 mg/day) reduced menstrual pain and the need for additional painkillers, taken over 2 cycles. Prunes and prune juice have many health benefits. Top 9 Natural Allergy Relief Home Remedies - Dr. Axe 1 week ago from draxe.com Eat an Anti-Inflammatory, Alkaline Diet. Both supplements are antioxidants, which have been shown to help with blood flow and erectile function. DOI: Trebatick J, et al. You may want to start slow, taking smaller amounts, to ensure that your body works well with the OPCs found in pine bark extract. Quality and active ingredients in supplements may vary widely from maker to maker. Vinpocetine is a well-known substance in the health-hacking community with a variety of claimed health benefits. This study adds to a body of research showing the benefits of Pycnogenol . Pycnogenol: A miracle component in reducing ageing and skin disorders. but is for informational and educational purposes alone. Systolic blood pressure measures how much blood is pumping from your heart to your arteries. A 2004 animal study also found that applying a gel containing pine bark extract sped up the wound-healing process. (2006). Regardless of what youre using it for, its best to start with the lowest possible dose. 4. There is limited evidence that it could be used in treating Attention Deficit Hyperactivity Disorder (ADHD). In one trial of 77 people with type 2 diabetes, pycnogenol (100 mg/day) for 12 weeks lowered both blood sugar levels and HbA1c, a marker of long-term blood glucose levels [31]. Diabetes-associated small blood vessel changes is the leading cause of diabetic ulcers. The information in our articles is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. Pycnogenol may stimulate the immune system. Here are some basic guidelines as reported by WebMD: While most studies do not indicate major side effects, pine bark extract may cause irritability and fatigue, and could interact with other drugs. are clickable links to medically peer-reviewed studies. , Allergy: "Leukotriene E4 plasma levels in adult asthmatic patients with variable disease severity. The U.S. Food and Drug Administration (FDA) does regulate dietary supplements; however, it treats them like foods rather than medications. However, some of these other pine bark extracts can have different active compounds, which may affect their biological activity. Pycnogenol accelerates wound healing and reduces scar formation [Abstract]. In mice, luteolin prevented inflammation and allergic response in the lungs and nose by inhibiting inflammatory cytokines: IL-4, IL-5, and IL-1 3 []. Masquelier was easily able to create a pine bark extract from materials that were otherwise known as waste. Reduces Pain. A sitz bath, which involves sitting in warm water for 10 minutes, twice daily, is helpful to patients with anal itching, aching or burning and is known as one of the best ways to get rid of hemorrhoids fast. It is found primarily in southwestern France and is used to help people with asthma, allergies, hay fever, and other health conditions.. Learn more about how to get even skin tone. A randomized placebo-controlled trial of 60 children with mild-to-moderate asthma found that those who took Pycnogenol may be able to reduce or discontinue their use of rescue inhalers more often than the placebo group [15]. The remaining compounds are phenolic acids, which may also have antioxidant activity [1, 2]. It also reduced LDL cholesterol at a slightly lower dose (125 mg/day) in those with type 2 diabetes in a clinical trial of 48 people after 12 weeks. Since components of Pycnogenol can be modified during digestion and absorption as well as by the liver, diseases that affect the gut or liver may increase or decrease its effects [84]. Another study in 2012 showed that Pycnogenol alone, at a dose of 75 mg/day, increased skin hydration by 8% after just 6 weeks; in women with dry skin at baseline the increase was 21%. Helps Increase Athletic Performance. Pycnogenol is considered possibly safe when taken orally or when applied topically as a cream or ointment. There have been a variety of health benefits linked to beta glucan, specifically with the beta-1 3d glucan form which has more biological activity than other types of polysaccharides. Higher doses (200 mg/day) may improve blood vessel health and function after 8 weeks according to a study of 23 people with heart disease [38]. . 2005 - 2023 WebMD LLC. But what makes this miracle ingredient so amazing? Results failed to show any efficacy of Pycnogenol or methylphenidate when compared to placebo. (13). So it . $31.99. A combination product with Pycnogenol (Lady Prelox) improved sexual function in a clinical trial of 83 healthy postmenopausal women after 8 weeks. In another study, 61 children with ADHD were given one mg per kg/day of Pycnogenol or placebo over four weeks. Treatment of ADHD with French maritime pine bark extract, Pycnogenol [Abstract]. American Cancer Society: "Pine Bark Extract.". Diindolylmethane, or DIM for short, is a plant indolea plant compound with health-promoting properties. Clearer skin, healthier hair there are a lot of claims about the health benefits of biotin. (2017). Ana spent years working with patients who suffer from various mental health issues and chronic health problems. In another trial, a combination supplement (Pycnogenol 60 mg/day, L-arginine 690 mg/day and aspartic acid 552 mg/day) improved erectile dysfunction and sexual satisfaction in men after 8 weeks. This includes supporting healthy blood circulation, acting as a natural anti-inflammatory, helping to generate collagen and hyaluronic acid for improved skin health and aiding in the production of endothelial nitric oxide which helps to dilate blood . Potential for allergy when taken orally or used on the skin. Healthline Media does not provide medical advice, diagnosis, or treatment. Pycnogenol has several benefits to your health and beauty. However, research on these two groups is limited [71, 15]. It is chronic venous insufficiency, a common disease among people who are obese or elderly and those who lead a sedentary lifestyle. Blazs G, et al. Forty-seven Japanese men with mild erectile dysfunction were given supplementation L-arginine and French maritime pine bark extract over a period of time. Note that the numbers in parentheses (1, 2, etc.) A small 2017 study examined the effects of pine bark extract in treating cardiovascular risk factors associated with menopause. Another highlight of grapes nutrition is the presence of polyphenols, which have been shown to decrease chronic inflammation. The usual recommended duration of treatment for topical application is 7 days for Pycnogenol cream and 6 weeks for Pycnogenol powder. Prenatal nutrition can be confusing. Rating: 100%. Trees of this pine have been naturalized in Australia and New Zealand, where most Enzogenol is now made [7]. With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. It should never be used as a replacement for approved medical therapies. Various brands of pycnogenol are available. Taking pycnogenol daily for 2 months seems to slow or prevent further worsening of retinal disease caused by diabetes, atherosclerosis, or other diseases. This Dr. Axe content is medically reviewed or fact checked to ensure factually accurate information. Pycnogenol is the leading ingredient in Isotonix OPC-3, Market America's best-. Pycnogenol is similar to grape seed extract and cocoa polyphenols as those are the three most common . There havent been any studies looking at long-term liver damage. 2005 - 2023 WebMD LLC. The specific tree from which the bark is extracted is called a maritime pine. The top benefits of nattokinase include the following: Regulate blood pressure. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. Its best to check with your doctor about the dosage, based on the symptoms you have and other possible conditions, prior to taking either pine bark extract or Pycnogenol. A study of 58 people with high blood pressure suggests that even lower doses (100 mg/day) may improve blood vessel health and reduce markers of high blood pressure (endothelin-1) after 12 weeks. A study of 32 people with heart failure lasting 12 weeks suggests that a combination of Pycnogenol with CoQ10 (PycnoQ10) may improve blood pressure, heart function, edema, and capacity for physical activity [40]. Pycnogenol treatment lowered the ACE-inhibitor dose required to control blood pressure, and lowered fasting glucose levels as well. But the actual bioavailability of this complex mixture is still unknown. But a month after pycnogenol was stopped, the symptoms came back, suggesting that it may need to be used regularly to achieve the benefits [41]. Some people seek to manage ADHD symptoms through an ADHD diet. Note that the numbers in parentheses (1, 2, etc.) returned. According to the lab results of 10 volunteers, a higher Pycnogenol dose (300 mg) may impact these enzymes after just 30 minutes [52]. In the placebo group, the retinopathy worsened; whereas, in the Pycnogenol-treated group, there was no deterioration. Pycnogenol is a compound of natural chemicals. Researchers suggest this effect may be due to reduced dopamine and adrenaline levels and increased glutathione levels. 11 Skin elasticity increased, and skin fatigue decreased significantly in this study as well, further lowering the wrinkling risk. Asthma is caused by inflammation in the lungs, which makes it hard to breathe. The researchers of the study propose that pycnogenol may reduce pain and cramps during retraining and rehabilitation in people with blood vessel problems [11]. One study suggests that Pycnogenol has no effect when given just 3 weeks beforehand, as it possibly requires a lag time to stabilize the immune response [17]. Posted on Thursday, August 14, 2014 The majority of this article is information obtained from the book "All About DIM" by Michael A. Zeligs, MD and A. Scott Connelly, MD. Moreover, Pycnogenol treatment reduced the use of painkillers. In another study, 45 men with ED were given 1.7 grams of L-arginine a day during the first month, 40 mg Pycnogenol twice daily during the second month, and the dose increased to three 40-mg Pycnogenol doses daily during the third month. Video: Why You Need Zinc and Where to Find It. Work with your pediatrician to see if there are contraindications for each child. A clinically studied blend of Pycnogenol and a special bilberry extract (called Mirtogenol ) has been shown to provide benefits for vision and eye health. Last medically reviewed on January 24, 2018. A high number signals high blood pressure. A 2006 study found that children who took a daily pine bark extract supplement for four weeks had significantly lower levels of hyperactivity. Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. Natural Factors Pycnogenol 25mg 60 Veggie Caps. In the control group, there were five thrombotic events; whereas the Pycnogenol-treated subjects only experienced nonthrombotic, local flare-ups. It can also be used for local application on the skin without the risk of side effects. The same study showed that a single, 200-mg Pycnogenol dose remained effective over six days in preventing cigarette-induced enhanced platelet aggregation. The supplement significantly reduced hot flashes, night sweats, mood swings, irregular periods, loss of libido, and vaginal dryness. Pycnogenol is the registered trademark name for a French formula. You can refer to the National Institutes of Healths dosage guidelines for specific conditions. For that reason, you should be careful taking pine bark if you have hypertension or diabetes. This makes it very hard to set a standard dose. The most effective blood sugar-lowering dose was 200 mg/day higher doses had no further benefit [33]. Beta 1-3D Glucan is recognized by cells in the immune system, and can modify your immune system responses. The women taking Pycnogenol also experienced improvement in fatigue, sleep, concentration, memory, dizziness, and mood, including less irritability. In a third study, 19 men with fertility problems were given 200 mg Pycnogenol daily for 90 days. Researchers suggest that Pycnogenol may reduce cough, night-awakenings, improve airway flow, and the need for additional asthma medication [16]. However, it can also be used topically. Pycnogenol is not approved by the FDA for medical use. In contrast, bleeding still occurred in the control group [61]. Placebo capsules were given to control subjects at the same times. Pycnogenol (100 mg/day) improved menopausal symptoms and quality of life in a clinical trial of 35 women after 8 weeks [68]. Helps maintain high vitamin C and E blood levels for their antioxidant effects. Moreover, Pycnogenol group either reduced or discontinued the use of asthma drugs. Patients were given 100 milligrams of Pycnogenol, a branded version of pine bark extract, for 12 weeks, with continued anti-diabetic treatment. A small 2012 study on postmenopausal women found that pine bark extract improved hydration and elasticity of skin. Pycnogenol (100 mg/day) may reduce leg swelling, spider veins, and cramps according to a study of 133 women with varicose veins who recently gave birth. DOI: Luzzi R, et al. While it may seem intimidating at first, counting macros is a common Erythritol is now one of the most popular natural zero-calorie sweeteners available. Moreover, Pycnogenol treatment led to an increase in sperm count and testosterone levels with lowering of blood pressure and cholesterol levels. Dr. Drew explains the benefits of probiotics for the gut microbiome and talks about the rise of leaky gut, and Dr. Steve shares how emotional stress can have real physical effects on the heart. Research indicates that Pycnogenol provides an increase in endurance performance of trained athletes. Researchers suggest that it may epigenetically turn off genes responsible for joint damage (ADAMTS) as well as reduce inflammation enzymes (MMP3) and cytokines (IL 1-beta) [47, 48]. A study of 50 mildly infertile men found that a combination of L-arginine, L-citrulline, roburins, and Pycnogenol (Prelox R) may improve sperm quality, volume, and concentration [75]. (8). First and foremost, start eating an anti-inflammatory Local Raw Honey (Bee Pollen) Considering how good it tastes, having some raw honey Apple Cider Vinegar (ACV) You can now find high-quality apple cider vinegar in . They include: We need more research to know for sure if pycnogenol helps treat these conditions. While OPCs found in this extract are mostly known for their antioxidant-producing benefits, these amazing compounds exude antibacterial, antiviral, anticarcinogenic, anti-aging, anti-inflammatory and anti-allergic properties. Perimenopausal women who took pine bark extract for eight weeks noticed decreased cholesterol and triglyceride levels. Sort By. Also, be sure to talk with your doctor first if you have an underlying medical condition or take other medications. SelfHacked has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. Here are 12 benefits of ginkgo biloba. Another study of 47 women found that supplementing with 30 mg Pycnogenol twice daily for over 1 month may reduce menstrual pain [73]. Circulation and Jet Lag on Long Flights. Speak with your doctor before supplementing. They could interact with medicines to suppress the immune system, chemotherapy drugs, and blood thinners. For asthma in children: 1 milligram per pound of body weight given in two divided doses. ( 4) Thus, this powerful extract works as a natural ear infection remedy while improving balance and preventing hearing loss. Dr. Steven Lamm did a great job at explaining the new benefits of pycnogenol. He learned about the seemingly omnipotent antioxidant within it and how those antioxidants increase the absorption of vitamin C. Continued research showed that the pine bark contained flavonols and bioflavonoids, which hold tissue-repairing properties. Pycnogenol is the registered trademark brand name of French maritime pine bark extract. Lets begin with asthma. This condition can be temporary or permanent however, some studies have indicated that pine bark extract may help alleviate these symptoms due to its high presence of antioxidants. According to some researchers, when you take Pycnogenol [8]: Research suggests that Pycnogenol may protect cells in the body against oxidative stress. Cigarette smoking increases platelet aggregation. It may cause side effects such as: Dizziness. Buy Healthy Origins Pycnogenol 100 mg (Nature's Super Antioxidant, Non-GMO, Gluten Free, Cardiovascular Support), . Pine bark extract contains active ingredients that can also be found in peanut skin, grape seed, and witch hazel bark. Note that each number in parentheses [1, 2, 3, etc.] The treatment was four 50 mg capsules of Pycnogenol. ( 1) 2. Remember to speak with a doctor before taking Pycnogenol. What gives pine bark extract its notoriety as a powerful ingredient and super antioxidant is that its loaded with oligomeric proanthocyanidin compounds, OPCs for short. Extracts can also be made from other pine barks, such as Pinus radiata, Pinus densiflora, Pinus thunbergii, and Pinus massoniana. Risks. In some people lung inflammation is caused by leukotrienes chemicals that are released by the body after a person encounters allergens. Some studies have suggested it may modestly improve blood pressure, cholesterol, and C-reactive protein. The authors attributed the negative results to the short duration of treatment and the low dosages of drug or Pycnogenol. chronic anal fissure may take more than 6 weeks to heal. The flesh of the grape contains approximately 1/20th-1/100th of the total antioxidant capacity of the seed or the skin. Pycnogenol may reduce glucose levels, but it doesnt appear to increase insulin production or insulin sensitivity. DOI: Chowdhury WK, et al. Finally, research suggests that Pycnogenol may improve triathlon time while possibly reducing cramps and post-running pain [10]. In one study, 200 mg a day of Pycnogenol taken three hours prior to the first cigarette for the day for two months significantly reduced cigarette-induced platelet aggregation. Clinical research suggests that Pycnogenol is possibly effective for improving athletic performance. Pycnogenol, an extract of French maritime pine bark, helps the body fight normal aging by supporting vascular health and healthy circulation. 1 Anti-Aging Beverage, An surprisingstudy found that pine bark extract was far better than aspirin at inhibiting smoking-induced clotting, using lower amounts without the bleeding often found when using aspirin. A popular variety is the pinus maritime or the maritime pine that grows exclusively along the coast of southwest France. According to a study of 11 patients with lupus, pycnogenol may reduce symptoms, inflammation, and oxidative stress [54]. Studies have shown that the tree bark can help decrease common symptoms including hot flashes, mood swings, irregular periods, and others. Pine bark extract may be the perfect treatment since its an antioxidant dynamo. However, its unclear how clinically effective Pycnogenol is for most of these conditions due to the low quality of evidence. Benefits, Nutrition, Uses & How It Compares vs. Blackberries. Researchers suggest it may boost sustained attention, memory, executive functions, mood, and reduce oxidative stress [19]. The study participants symptoms started to return a month after they stopped taking pine bark extract. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. The outcome showed significant healing when compared to those subjects who were not given any drug or remedy, concluding that Pycnogenol may be an effective remedy for healing of surgery-related lesions. They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again. Arginine is a non-essential amino acid because most humans can make it in their bodies. Pycnogenol lowered leukotrienes as well. As a skin cream, its safe to use for about seven days. There's good evidence that pycnogenol helps with eye damage caused by diabetes.